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Allinizio degli anni novanta, gruppo di Holst si rese conto che un tipo di GLP-1 troncato ( proglucagone 78-107-amide ) era estremamente interessante e, in studi successivi, dimostr che esso inibiva fortemente la motilit gastrica e la secrezione esocrina gastrica e pancreatica 37 , coerente con un ruolo importante di questo ormone come regolatore della funzionalit del tratto gastrointestinale superiore

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This weight loss magnitude is clinically meaningful for arthritisstudies suggest that even 5-10% body weight reduction can improve joint symptoms and reduce arthritis progression risk

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Rachitskaya and Allan

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As a result, they can be more challenging to manufacture and may take longer to dissolve, requiring extended wear times

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Tu, Sand W.B

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Hence, the incidence rate of gastrointestinal AEs associated with GLP-1RA use cannot be estimated

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