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They're not a magic bullet, and consistency with diet and exercise remains crucial

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New indications underwriters cant ignore Fatty liver disease (MASH) Formerly known as NASH, metabolic dysfunction associated steatohepatitis is a form of fatty liver disease associated with significantly increased risks of diabetes, heart failure, kidney disease, cirrhosis, and liver cancer

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Sinha R, Rapamargaritis D, Sargeant JA, Davies MJ (2023) Efficacy and safety of tirzepatide in type 2 diabetes and obesity management

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The hepatic side effects cholestasis, hepatitis, jaundice and hepatic failure have rarely been reported

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Coffee and caffeine: these relax the lower esophageal sphincter, particularly problematic on an empty stomach

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The REMOVAL trial assessed benefit of metformin in T1D and cardiovascular risk and showed no evidence of sustained A1C reduction, and no benefit in carotid intima-media thickness (the studys primary endpoint)

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