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They're not a magic bullet, and consistency with diet and exercise remains crucial

New indications underwriters cant ignore Fatty liver disease (MASH) Formerly known as NASH, metabolic dysfunction associated steatohepatitis is a form of fatty liver disease associated with significantly increased risks of diabetes, heart failure, kidney disease, cirrhosis, and liver cancer
Sinha R, Rapamargaritis D, Sargeant JA, Davies MJ (2023) Efficacy and safety of tirzepatide in type 2 diabetes and obesity management
The hepatic side effects cholestasis, hepatitis, jaundice and hepatic failure have rarely been reported
Coffee and caffeine: these relax the lower esophageal sphincter, particularly problematic on an empty stomach
The REMOVAL trial assessed benefit of metformin in T1D and cardiovascular risk and showed no evidence of sustained A1C reduction, and no benefit in carotid intima-media thickness (the studys primary endpoint)