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Dulaglutide is a long-acting GLP-1RA used for T2DM with demonstrated cardiovascular benefits.[10] Liraglutide, another long-acting GLP-1RA, is used for T2DM and obesity management and is under investigation for Alzheimers disease and metabolic-associated hepatic steatosis.[4] Lixisenatide, a short-acting GLP-1RA, shows comparable efficacy to exenatide and liraglutide for T2DM management, and is now combined with insulin glargine.[23] Semaglutide, available in injectable and oral forms, has demonstrated benefits in promoting weight loss, reducing risk of cardiovascular events, and slowing progression of diabetic CKD.[24] Finally, tirzepatide is a dual agonist for receptors of GLP and glucose-dependent insulinotropic polypeptide (GIP), a hormone released from the intestines in response to macronutrients.[25] These two mechanisms of action have synergistic glucose-lowering and weight loss effects with lower side effect rates than other GLP-1RAs.[25] Tirzepatide has also been shown to result in blood pressure reduction, obstructive sleep apnea control, and improved cholesterol in T2DM patients.[5] Table

Missing doses or taking them at inconsistent intervals reduces the steady-state drug levels that produce optimal appetite suppression and metabolic effects

In a small study of 20 people with obesity, GLP-1 drugs restored the function of natural killer (NK) cells, a part of the immune system that helps destroy cancer cells

Cognitive-behavioral therapy (CBT) specifically adapted for eating behaviors can help patients develop awareness of food-related thought patterns, identify triggers for intrusive food thoughts, and implement cognitive restructuring techniques

Review Etiology of HFpEF Based on population-based studies conducted in the United States, more than 6 million people over the age of 20 have HF at this time

Incidence of DR and NAION During the 2-year follow-up period, 5037 (2.7%) individuals in the GLP-1 RA group developed incident DR compared with 4938 (2.7%) individuals in the group without GLP-1 RA prescriptions (n = 185 066 per group