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Observing rs-fMRI, the functional brain connectivity in GLP-1R KO mice was significantly lower than that in the WT group (p=0.0032 for gFCD, p=0.0002 for whole-brain correlation, p<0.0001 for ALFF)

GLP-2 (Tirzepatide) is a dual incretin receptor agonist widely utilized in preclinical research involving metabolic regulation, incretin signaling, and energy balance-associated biochemical pathways

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We assessed the prespecified secondary outcome metabolic syndrome severity z-score (MetS-Z), abdominal obesity (estimated as android fat via dual-energy X-ray absorptiometry), and inflammation marker high-sensitivity C-reactive protein (hsCRP)