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Medi-Cal's decision reflects the growing pressure on public insurance programs to manage these expenses

doi: 10.1111/jdi.12445 12 TakedaYFujitaYYanagimachiTMaruyamaNBesshoRSakagamiHet al

Standard dosing follows a step-up schedule, increasing from 0.25 mg to 2.4 mg, as used in most trials

This study does not require ethical review or approval but must comply with relevant laws and regulations

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All patients were required to have continuous enrollment of at least 12 months before cohort entry and meet eligibility criteria for one of the five cohort studies defined below (study design diagrams depicted in Supplementary Figs