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Description
The Allosteric Discovery: A New Binding Paradigm Chugai Pharmaceutical's discovery program challenged this consensus by shifting the focus from the orthosteric binding site (the pocket occupied by endogenous GLP-1 and peptide agonists) to potential allosteric sites within the GLP-1 receptor's TMD
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This hormone is naturally produced in the gut and helps regulate blood sugar levels by stimulating insulin production
So the framing I love comes from Brad Scheinfeld uh and others like him
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Appendicitis is a medical emergency that occurs when the appendix, a small tube-shaped organ attached to the large intestine, becomes inflamed

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