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Description

Several emerging technologies are shaping the next generation of peptide drug analysis: Top-down mass spectrometry for intact peptide analysis Multidimensional LC-MS workflows AI-assisted spectral interpretation Ultra-high-resolution Orbitrap mass spectrometry Top-down mass spectrometry allows direct analysis of intact peptide molecules without enzymatic digestion

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Each ligand is tested for potency and specificity toward its target receptor using our proprietary cell-based metabolic bioassays

Further docking studies with aldose reductase, DPP-4, PPAR, and glucosidase revealed that chalcones 13, 16, 17, 18, and 19 (Figure 4) inhibited DPP-4 activity more effectively than others

For the generation of FGF21 Alb-KO mice, the FGF21loxP (B6.129S6(SJL)-Fgf21tm1.2Djm/J) line was crossed with B6.Cg-Tg(Alb-cre)21Mgn/J (Alb Cre ) mice (Jackson laboratory)