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For instance, metformin can achieve its glucose-lowering effects through the gut-liver axis (Tobar et al., 2023)

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Closing K + channels causes depolarization, allowing Ca ++ entry to stimulate insulin secretion

The natural release of dopamine is altered to rely on the drug

References El Ansari W, Elhag W (2021) Weight regain and insufficient weight loss after bariatric surgery: definitions, prevalence, mechanisms, predictors, prevention and management strategies, and knowledge gaps-a scoping review