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Provide individualized care and monitor patients

40,41 A study using nationwide registers in Nordic countries showed that with an additional adjustment for laboratory results (glycated hemoglobin, albuminuria, eGFR), there was no difference in the risk of AF between SGLT2i users and GLP-1RA users in Swedish cohort (HR=0.90 [95% CI: 0.79 to 1.01]) and in Danish cohort (HR=0.92 [95% CI: 0.79 to 1.08])

Two years ago, one of these drugs, semaglutide, also was approved as an obesity treatment in the U.S., sparking an explosion in public interest

A recent case report of a woman who was diagnosed with MTC while on a GLP-1 agonist showed no change in her calcitonin levels ( Gastroenterology

Studies have shown (83) reported that GLP-1R is highly expressed in normal pancreatic secretory cells, expressed at low level in pancreatic acinar cells, not expressed in pancreatic duct cells, and expressed at low or no levels in human pancreatic cancer tissues

59 Compared to human GLP-1 (Figure 1A), the alanine residue at the second position of the N-terminus in GLP-1 RAs and a dual GLP-1/GIP RA (except for liraglutide) has been substituted to prevent metabolism by DPP-4 (Figure 1)