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Mechanistic insights into GLP-1 receptor agonists and reward pathways

The risk of severe hypoglycemia and weight gain is less than sulfonylureas but still must be considered in patients treated with meglitinides

That would be expected, given that obesity and excess weight are risk factors for heart attack and stroke

In the next five years, as these advanced drugs enter the market, Richards predicts that people and their doctors could effectively choose the exact weight they desireand that is a scary concept.

GLP-1 agonists and risk of suicidal thoughts and behaviours: confound by indication once again

However, some healthcare providers may prescribe GLP-1s off-label to people with type 1, as research indicates they can improve blood sugar levels, manage weight, reduce the need for insulin, and offer protection for the heart and kidneys