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Systematic reviews confirm their safety and effectiveness compared to placebo, and recent studies highlight their impact even in challenging cases systematic review of GLP-1 therapy effectiveness

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This review delineates the multifaceted mechanisms by which GLP-1RAs exert ocular benefits, including retinal ganglion cell (RGC) rescue via calcium channel and GABAergic modulation, mitochondrial protection through PINK1/Parkin-mediated mitophagy and ERK1/2-HDAC6 signaling, as well as potent anti-inflammatory effects via cytokine reduction and immune cell recruitment inhibition

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Additionally, the role of GS as an efficient hepato-protecting agent was also examined through its possible modulation of antioxidant response elements