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N Engl J Med 392:958971 Wilding JPH, Batterham RL, Davies M et al (2022) Weight regain and cardiometabolic effects after withdrawal of semaglutide: the STEP 1 trial extension
New opportunities lie in: Expansion into emerging markets with tailored GLP-1 therapies Development of combination therapies to enhance efficacy Investment in digital health platforms for patient engagement By 2035, the GLP-1 Drug Market is expected to achieve substantial growth and innovation

Outlook Depending on the molecule (native or recombinant long-acting) and the route of administration, GLP-1 analogs have broad pleiotropic action on metabolism
Diabetes 44:12491258 Kahn SE, Haffner SM, Heise MA et al (2006) Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy

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