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Insomnia becomes more commonly reported

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weight regain occurs after discontinuation STEP 5 (extended duration, N = 304): 104-week treatment duration (2 years) Mean weight loss: 15.2% at week 104 Weight loss plateaus between weeks 60 and 68, then remains stable with continued treatment The consistency across trials is notable

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Saline solution can sometimes cause precipitation depending on the peptide formulation