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Loss of hepatic AMP-activated protein kinase impedes the rate of glycogenolysis but not gluconeogenic fluxes in exercising mice

doi: 10.1093/ejendo/lvad098 37 AbdallaMAShahNDeshmukhHSahebkarAstlundhLAl-RifaiRHet al

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[DOI] [PubMed] [Google Scholar] 21.Samols E., Marks V

The phase 3 Exenatide-PD3 trial found no benefit over 96 weeks, with off-medication motor scores worsening in both arms and no significant difference between them (Vijiaratnam et al., 2025)

So there is a little bit of concern about that. Its a concern that has been pervasive enough for existing drugs that Lilly released a commercial ahead of the 2024 Oscars urging against vanity use