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However, the trial did not demonstrate statistically significant improvement in fibrosis stage, which determines long-term prognosis

However, based on preclinical data and early human trial findings, glucagon receptor co-activation in the context of concurrent GLP-1R and GIPR agonism is hypothesised to: Increase energy expenditure, potentially by promoting thermogenesis Enhance hepatic fat oxidation, which may reduce liver fat content Contribute to appetite suppression through central nervous system pathways These GCGR-mediated mechanisms are largely derived from preclinical and indirect human data and require confirmation in larger trials

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Gastroparesis symptoms include acid reflux and stomach pain

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In addition, metreleptin could be effective in acquired GL and PL