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New and sensitive ways to measure blood hormone levels then allowed researchers to show a hormone called GIP (glucosedependent insulinotropic polypeptide) was partly responsible for the incretin effect

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GIP receptors are also found in areas of the brain associated with satiety and reward signaling.When tirzepatide activates both receptor types, it: Tirzepatide's actions on blood sugar are glucose-dependent, meaning it: Additional systemic effects include: Talk with your provider if you are pregnant, plan to become pregnant or breastfeed, or have a history of: Some side effects require prompt medical attention, including: Your knownwell care team will review your health history, medications, and safety considerations before prescribing Zepbound and will continue to support you throughout treatment

If nausea is severe or persists beyond eight weeks, contact your PlexusDx clinician to discuss dose adjustments or alternative formulations

doi:10.1056/NEJMoa2403347

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