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Nausea increases with dose, as expected, but the slope is gentler than with semaglutide
on the other hand, GLP-1 analog exendin-4 could modulate these inflammatory conditions by affecting smooth muscles cytokine and chemokine expression
Dulaglutide 0.75 mg (n = 251) resulted in a mean increase in 24-h HR of 1.3 bpm, whereas a 3.5-bpm increase in HR was observed at the end of the study for the 1.5-mg dose (n = 254)
doi:10.1016/S0140-6736(25)02165-8
The result is the prolonged fullness patients describe as feeling "the meal in their chest" hours later, often accompanied by reflux as stomach contents back up against a relaxed lower oesophageal sphincter
