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allow to dry Device Preparation : Check pen for damage Verify medication is clear and colorless (Zepbound) or clear and colorless to slightly yellow (Wegovy) Attach new needle to pen Prime pen according to manufacturer instructions (removes air) Injection : Pinch skin at injection site Insert needle at 90-degree angle Press injection button and hold until dose delivered (may take 5-10 seconds) Count slowly to ensure full dose delivery Remove needle and release skin Post-Injection : Do not rub injection site Apply gentle pressure if needed Dispose of used needle immediately in sharps container Recap pen and return to refrigerator For vial formulations with syringe (Zepbound vials): Preparation (same as above for site selection and cleaning) Dose Drawing : Remove vial protective cap Wipe rubber stopper with alcohol swab Draw air into syringe equal to prescribed dose Insert needle into vial and inject air Invert vial and slowly draw prescribed dose into syringe Check for air bubbles

In a second study, Do GLP-1 Medications Pay for Themselves

Semaglutide Constipation: What Patients Should Expect Semaglutide constipation is commonly reported during early treatment or dose adjustments

Subcutaneous Injection Technique

Ongoing cost commitment: Benefits typically require sustained use over months, representing significant financial investment

This makes Defy the most expensive option on this list, but it's also the most clinically comprehensive