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Importantly, GLP-1 injection into the ARC was shown to decrease the activity of agouti-related peptide (AgRP) neurons and their strong orexigenic effect and to activate the pro-opiomelanincortin (POMC) neurons, which are prominent in satiety via melanocortin pathways [50,55,56]

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The cells were exposed to a range of treatments: TGF-1 (10 ng/ml, R&D Systems Inc., Minneapolis, USA), IL-1 (10 ng/ml, R&D Systems Inc., Minneapolis, USA), MCC950 (10 M, Selleck, Houston, TX, USA), 3PO (10 or 30 M, Selleck, Houston, TX, USA), liraglutide (10, 100 or 1000 nM, Selleck, Houston, TX, USA), and sodium L-lactate (20 mM, Sigma-Aldrich, St

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Package insert / product label Generic name: exenatide Dosage form: injection Drug class: GLP-1 Drugs Medically reviewed by Drugs.com