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Sugars like mannitol, trehalose, and sucrose can stabilize peptide structure in solution

At the end of the study, all mice were anesthetized with 1% sodium pentobarbital solution (50 mg/kg, intraperitoneal injection)

This led to an unprecedented worldwide demand for the drug that surpassed even the manufacturers expectations and led to severe supply issues

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"American Diabetes Association Highlights Novel Agent Retatrutide Results in Substantial Weight Reduction for People with Obesity and Type 2 Diabetes During Late-Breaking Symposium." diabetes.org, Accessed July 10, 2023, Lancet Diabetes & Endocrinology

Understanding this relationship helps patients take preventive measures while benefiting from this weight management therapy