glp 1 gila monster venom… and weight loss? 🦎 It sounds wild, but it's true. GLP-1 medications were inspired by a hormone first discovered in the saliva of a Gila monster. On this week's Lessons from the Gila Monster:

It helps control blood sugar when combined with diet and exercise

If access disappears after 2027, patients will likely stop therapy, regain weight, and end up back where they started

Steroidogenic factor 1 directs programs regulating diet-induced thermogenesis and leptin action in the ventral medial hypothalamic nucleus

49 The glucose-lowering potential of cotadutide (a GLP-1/GCG RA) was seen in a Phase IIa study, in which the post-prandial area under curve was significantly reduced, and 3.4% weight loss was achieved after 49 days, in adults who are overweight with T2D

Kim SJ, Nian C, Karunakaran S, Clee SM, Isales CM, McIntosh CH

The early impact on body weight can also be assessed at this time