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This trial used the same doses (0.5 and 1.0 mg) and dose-escalation regimen as SUSTAIN CHINA MRCT (ClinicalTrials.gov identifier: NCT03061214), a large multiregional phase 3 clinical trial including approximately 70% subjects from China

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Wall thinning and aneurysmal dilation in the sub-tricuspid region, RV outflow tract, or base also known as the triangle of dysplasia. Progression of disease tends to be from the base to the apex

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These studies are much more clear-cut in animals than in humans, likely because there are many more confounding factors in humans, including pre-existing mental health conditions and psychosocial factors