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This effect was not seen in the normal-weight rats

In unhealthy conditions, especially when excess calorie intake is chronic, fat cells increase in size as they accumulate more fatty acids, but their numbers diminish

doi: 10.1007/s12519-024-00814-1

A Long-Acting FGF21 Molecule, PF-05231023, Decreases Body Weight and Improves Lipid Profile in Non-human Primates and Type 2 Diabetic Subjects

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