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Limitations The major limitations of the studies that are included in this systematic review are the enrollment of healthy subjects and insufficient data in conditions that might affect pharmacokinetics (e.g., kidney dysfunction)

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Gastrointestinal discomfort and nausea are the most common side effects, but those related to patients physical appearance often receive the most attention

The hunger-reducing mechanisms of GLP-1 drugs, as well as their side effects, may contribute to dehydration.