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Deng YW, Shu YG, Sun SL

Current guidelines recommend metformin as a first-line therapy for type-2 diabetes

Prescription GLP-1 medicines can cause side effects including nausea, vomiting, diarrhoea, constipation, and abdominal discomfort

Although GLP-1 treatment led to improvements in blood sugar, blood pressure, and blood lipids (cholesterol and triglycerides), those gains didnt last once medication stopped

These may include heart rate, blood pressure, glucose measures, liver markers, and adverse events that require medical review

doi: 10.1016/j.cell.2023.11.040
