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Starting BMI 32 and current BMI 24

A network meta-analysis comparing the effects of glucose-lowering therapy on body weight and blood pressure indicates that the greatest efficacy for reducing body weight is seen with subcutaneous semaglutide followed by the other GLP-1 RA and SGLT2i, and the greatest reduction in blood pressure is seen with the SGLT2i and GLP-1 RA classes [224]

Patients also often notice temporary bouts of fatigue when starting the drug

[DOI] [PubMed] [Google Scholar] 20.The effect of semaglutide and GLP-1 RAs on risk of nonarteritic anterior ischemic optic neuropathy

J Clin Endocrinol Metab 1973;37:826-8.PubMed 6

Unlike GLP-1RAs, DPP-4is have no significant impact on body weight due to the limited enhancement of GLP-1 activity [51,52,53]