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What should patients, physicians, insurers, policy makers, and researchers know about GLP-1 cost, access, and safety
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Third, these new results show convincingly that major adverse CV events benefits are independent of the structural basis of the GLP-1 receptor analogue, assuaging concerns that exendin-4-based agonists are less effective than human GLP-1-based molecules.
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Discussion In this study, we have identified how single amino acid substitutions to exendin-4 can dramatically enhance insulin secretion via modulation of GLP-1R binding kinetics, biased signaling, and trafficking
