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Glucose plays a central role in that process

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At 24 weeks, mean percentage decrease in weight (primary outcome) ranged from 7.2% to 17.5% with different retatrutide doses compared with 1.6% with placebo
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In people with overweight/obesity and non-diabetic CKD who were included in the SMART study, 2.4 mg semaglutide once weekly versus placebo reduced UACR by 52% at 24 weeks of treatment (87)
