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Why is fragmented care a concern with GLP-1 therapies

FITC-agonist was added for 30 min at 37 C to induce internalization, then removed and washed with cold HBSS to arrest further endocytosis, and cells treated with 500 mM ice-cold sodium 2-sulfanylethanesulfonate (MesNa), a membrane-impermeable reducing agent, in alkaline TNE buffer (100 mM NaCl, 50 mM Tris-HCl, pH 8.6) to cleave BG-SS-biotin specifically from cell surface receptors

If you take insulin or sulfonylureas, your doses may need to be reduced when starting a GLP-1 medication to prevent hypoglycemia (dangerously low blood sugar)

[DOI] [PMC free article] [PubMed] [Google Scholar] 62.Lee S.-Y., Wu S.-T., Du C.-X., Ku H.-C

Female patients make up nearly 65% of GLP-1 users nationwide, and around 5.2% of women with obesity are prescribed a GLP-1 medication (compared to 4.2% of men)

In comparison, compounded versions of GLP-1 drugs often cost $400 or more per month, and these unapproved alternatives come with significantly higher health risks