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Once released into the bloodstream, GIP and GLP-1 potentiate glucose-stimulated insulin secretion (GSIS) by pancreatic beta cells, regulate glucagon secretion from pancreatic alpha cells, and exert anorectic actions by binding to their receptors, which are expressed in different regions of the central nervous system involved in the regulation of appetite [1,2,76,77,78]

Studies have shown that patients taking Tirzepatide weekly for 72 weeks can expect to lose between 15% and 22.5% of their body weight

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Group, Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial, Lancet, 373 (2009) 473481