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Description
Your GP may consider: Dose adjustment : temporarily reducing or pausing Saxenda to assess symptom resolution Investigation : blood tests (including amylase/lipase if pancreatitis suspected), liver function tests, or imaging if clinically indicated Alternative treatments : if side effects are intolerable despite optimal management Regular follow-up appointments are essential when taking Saxenda

doi: 10.1210/jc.2018-01176

PMID 40196945

This pharmacokinetic behavior supports the titration-based dosing strategies used in the ATTAIN and ACHIEVE trials, where the starting dose is low and gradually increased over several weeks to the target maintenance dose

Also, pharmacological activation of the GLP-1R in the VMH by Ex-4 reduces food intake, activating mTOR signaling, indicating that glucose metabolism and inhibition of AMPK are both required for this effect [244]

A once-weekly combination drug is still a ways off, but research so far is encouraging
