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Starting too aggressive can cause: Different GI effects than you're used to Unexpected energy fluctuations Appetite changes that don't match your tirzepatide experience Give yourself one week at your starting dose to see how the glucagon piece hits you specifically

Semaglutide works exclusively on GLP-1 receptors scattered throughout the brain, stomach, and pancreas

| Take home message According to data from two randomised controlled trials (STEP 1 and SUSTAIN 8), up to 40% of the weight lost on semaglutide (Wegovy/Ozempic) may be from lean mass

Despite existing limitations, spontaneous reporting may be the best way to find rare AEs

32 , 4649 This has stimulated interest in their potential in other chronic diseases, particularly those with inflammatory components

Widespread availability through mail-order and websites raise concerns about safety and legitimacy