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Acute liver failure (ALF) Acute liver failure (ALF) is a severe, rapidly progressive condition that leads to hepatic encephalopathy and synthetic dysfunction within 26 weeks or less, and is accompanied by an INR (International Normalized Ratio) of 1.5 in patients without cirrhosis and without previous liver diseases [124]

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doi: 10.1097/HEP.0000000000000696 8