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However, the lack of available evidence has limited researchers from making definitive conclusions on this potential association

Everything comes with risks

However, restarting typically requires re-titration and may involve temporary side effects again

Future of GLP-1 receptor agonists In a related editorial, Thiara noted that although Tang and colleagues found that GLP-1 receptor agonists and SGLT2 inhibitors had a similar effect on ADRD, the team did show that isolating semaglutide, the newest and most potent GLP-1 receptor agonist on the market, showed decreased risk of ADRD compared with SGLT2 inhibitors. Both studies had limitations, including short-term follow-up, low dementia event rates and confounding variables, Thiara wrote

[DOI] [PubMed] [Google Scholar] Ugleholdt R, Poulsen ML, Holst PJ, Irminger JC, Orskov C, Pedersen J, Rosenkilde MM, Zhu X, Steiner DF, Holst JJ

This wasnt a simple business decision