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Thus, the dual effects of GLP-1RAs in breast cancer and EC may be linked to individual variations in macrophage polarization (136)

Centenera M

Indeed, sex-specific responses to dietary patterns may be influenced by biological differences, such as differences in hormonal regulation and body fat distribution

The mechanism of action is the same as GLP-1, including stimulation of insulin secretion, slowing gastric emptying, and reducing postprandial glucagon secretion in a glucose-dependent fashion

The co-activation of both receptors in retatrutide may therefore reduce appetite through two partially independent central pathways, which could explain why the compounds appetite-suppressing effects exceed what GLP-1R agonism alone achieves