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As such, the effect of GLP-1RAs on DR should be viewed with caution

In subjects with T2DM, weekly administration of tirzepatide at doses of 5 mg, 10 mg, or 15 mg was associated with greater weight loss compared to placebo ( 6.3 kg, 8.4 kg, and 9.4 kg, respectively), and 1.7 kg, 4.8 kg, and 7.2 kg greater weight loss compared to selective GLP-1 receptor agonists, demonstrating a dose-dependent effect sustained for up to 2 years [48]

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Amylin dose-dependently suppresses arginine-mediated glucagon secretion in rats [597] whereas pharmacological inhibition of amylin signaling enhances glucagon secretion [598]

Furthermore, in neurons exposed to amyloid- oligomers, the insulin receptors are removed from the plasma membrane, suggesting that a state of neuronal insulin resistance occurs in AD [151,156]
