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10 In particular, semaglutide was most successful at reducing alanine transaminase (mean difference, 14.70 U/L), aspartate transaminase (mean difference, 9.32 U/L), g-glutamyl transferase (mean difference, 16.56 U/L), and liver stif fness measurement (mean difference, 3.08 kPa) compared with the other medications studied, whereas liraglutide demonstrated efficacy in reducing subcutaneous adipose tissue (mean difference, 30.27 cm 2 ) and liver fat fraction (mean difference, 5.16%)

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This is a significant quality-of-life outcome, as CPAP adherence is a persistent challenge, studies estimate that 30 to 50 percent of patients prescribed CPAP do not use it consistently