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Efficacy and safety of GLP-1RAs for people with obesity: A systematic review based on RCT and Bayesian network meta-analysis

A critical reassessment of historical failures reveals that many appetite-related peptide programs were abandoned not because their biology was flawed, but because early development conflated dose-dependent adverse effects or behavioral complexity with intrinsic target unsuitability ( The GLP-1 experience provides an instructive counterexample

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Clinical trials show that patients on GLP-1 therapy lose an average of 12 pounds per week during active titration, with cumulative losses ranging from 1020% of body weight over 6 months when combined with healthy eating and physical activity