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In the SURPASS-4 trial, patients receiving tirzepatide experienced an average weight loss of 7.1 kg (15.7 lbs) after 52 weeks, compared to 2.5 kg (5.5 lbs) in the insulin glargine group[6]. The SURMOUNT-1 trial tested the ability of tirzepatide to produce weight loss in people with obesity who do not have diabetes

Among participants 4 to 66 years of age with acquired hypothalamic obesity, setmelanotide, a melanocortin-4 receptor agonist, led to significantly greater reductions in body-mass index and hunger...

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Tirzepatide, a dual GLP-1/GIP receptor agonist has been approved for glycaemic control in type 2 diabetes as well as for obesity management leading in up to 22.5% WL in phase 3 obesity trials