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Fatty Liver Disease (MASLD/MASH): Reduction of liver fat by ~ 82-86%

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doi: 10.1016/S2213-8587(19)30086-5 55 PykeC.HellerR

Excess adiposity contributes to dysregulation of the hypothalamic-pituitary-gonadal axis through increased aromatization of androgens to estradiol within adipose tissue, which may suppress hypothalamic-pituitary gonadotropin signaling, along with inflammatory signaling and alterations in sex hormone-binding globulin dynamics

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