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C Increased intensity of immunofluorescent staining for caspase-3 (Cas3) in the ventromedial hypothalamic nucleus
NAD+ may help to boost metabolism by increasing the activity of certain enzymes involved in energy production
The agency also flagged dosing errorsparticularly in multi-dose vialsand called for stronger oversight
17 Figure 12: PIONEER 6 trial design Source: Clinical Study Report
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The food-reward suppressing effect of GLP-1R stimulation needs to be confirmed in the target preclinical and clinical populationobese subjects
