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By inhibiting osteoblast differentiation of VSMCs, GLP-1RAs can ameliorate phosphate-induced vascular calcification, which is mediated by the AMPK/mTOR pathway or AMPK/receptor activator of nuclear factor kappa B ligand (RANKL), as occurs in the osteoblast differentiation of VSMCs [128, 129]

Instead, prioritize lean proteins like chicken and fish, low-sulfur vegetables such as spinach, green beans, and zucchini, and easily digestible carbohydrates like white rice or plain oatmeal during the initial adjustment phase

Less severe but still problematic gastrointestinal reactions warrant dose holds and systematic side effect management

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