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Interpretation of Results Efficacy There is clear and consistent evidence from 4 placebo-controlled DB RCTs that semaglutide evokes a statistically significant weight loss that is also clinically significant according to the clinical expert consulted by CADTH on this review

Navigating the financial aspects of weight loss medications, specifically Tirzepatide, is crucial, as it can be expensive without insurance coverage

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Constipation associated with Mounjaro is typically mild to moderate and tends to improve over time as the body adjusts to the medication

Second, the onset of milk production after delivery also showed no significant difference between the two groups

Limited options NICE points out that, until now, people with obesity have had limited treatment options and there is a large unmet need in this population