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Beyond these, in the pre-clinical space, over 25 candidates have been disclosed, but our analysis of patents, company disclosures, and early-stage publications identifies nearly 70 additional undeclared pre-clinical programs

* BRET : Bioluminescence resonance energy transfer BSA : Bovine serum albumin CyOFP : Cyan-excitable orange fluorescent protein DERET : Diffusion-enhanced resonance energy transfer FCS : Fluorescence correlation spectroscopy FITC : Fluorescein isothiocyanate GFP : Green fluorescent protein GLP-1(R)(A) : Glucagon-like peptide-1 (receptor) (agonist) GUV : Giant unilameller vesicle MCD : Methyl--cyclodextrin Nb37 : Nanobody-37 POPC : 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine T2D : Type 2 diabetes TMR : Tetramethylrhodamine TR-FRET : Time-resolved Frster resonance energy transfer

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Acarbose is therefore a valuable option for the management of type 2 diabetes and, as the only oral antidiabetes agent approved for the treatment of prediabetes, can help to improve clinical management across the dysglycaemic disease continuum.
