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[DOI] [PubMed] [Google Scholar] 4.Stumvoll M., Goldstein B.J., van Haeften T.W

However, a drawback of these medicines has been the necessity for administration by subcutaneous injection, which limits patient utilization and may reduce opportunities for fixed-dose combination treatments with other small-molecule drugs

Two studies were published in the impactful New England Journal of Medicine [Reference Weghuber, Barrett and Barrientos-Prez1,Reference Arslanian, Hannon and Zeitler2], research motivated, as noted by the authors, in no small measure precisely because the currently approved medications for pediatric obesity and type 2 diabetes have proven to be limited in their effectiveness and fraught with adverse events [Reference Woodard, Louque and Hsia3]

Sudden inflammation of the pancreas may occur with these medications, though it is rare

The evidence base is thin compared to pharmaceutical options

Albiglutide once weekly also showed a cardiovascular benefit but is no longer marketed, as mentioned previously (27)