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Although lifestyle intervention, sodiumglucose cotransporter 2 (SGLT2) inhibitors, incretin-based therapies, and liver-directed treatments have broadened the therapeutic framework for this overlap phenotype, prospective evidence specifically addressing patients with coexisting MASLD and HFpEF remains limited

Concerns include early treatment adjustment effects, individual sensitivity, and overlapping metabolic or psychological factors

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This guidance specifically notes that patients may not readily disclose off-label aesthetic use of these medications, highlighting the importance of comprehensive medication histories [45]

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