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Contraindications or health conditions Semaglutide is contraindicated in certain conditions, such as personal or family history of medullary thyroid cancer (MTC) or multiple endocrine neoplasia type 2 (MEN 2 syndrome), those with a history of allergic reaction to semaglutide, pancreatitis, or gallbladder issues

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On the other hand, castrated females would not only respond similarly to intact ones, but treatment with GLP-1As could reverse part of the metabolic problems associated with estrogens reduction (Handgraaf et al., 2018

The cardiovascular outcome data for this class is, at this point, one of the strongest evidence bases in preventive medicine

This can be particularly helpful for those experiencing nausea or fullness from semaglutide, as it minimizes the amount you need to consume
