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Schubert MM, Astorino TA, Azevedo JL, Jr

Research shows that stopping or pausing semaglutide therapy can trigger rapid rebound weight gain because your appetite-regulating hormones resume baseline function

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Furthermore, GLP-1R activation can mitigate liver inflammation and fibrosis by suppressing the NF-B signaling pathway and downregulating pro-inflammatory cytokines like tumor necrosis factor (TNF-) and Interleukin-6 (IL-6) [47, 48]

Some providers also use microdosing approaches with tirzepatide or adjust timing to address plateaus