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In clinical studies, GLP-1 receptor agonists have been associated with modest reductions in LDL cholesterol and total cholesterol, with more variable effects on triglycerides depending on the specific agent and study population

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[22] [23] Baseline assessment should be considered before initiating tirzepatide in high-risk patients, including those over 65 years of age, individuals with pre-existing gastrointestinal disorders, patients on concurrent metformin or acid-suppressing medications, and those following restrictive diets

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Tirzepatide works by stimulating two natural hormone pathways: GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide)

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If you are escalating your dose during this period, expect a temporary return of heightened sensitivity with each increase

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