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Why Patience Matters In the pivotal obesity trials, total weight loss with semaglutide and tirzepatide was assessed over about 6872 weeks (roughly 1618 months)
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Glp1r Lck/ mice retain normal Glp1r levels in spleen and PBMCs (34), whereas mice with GLP-1R deletion in the Tie2 expression domain ( Glp1r Tie2/ ) show complete loss of Glp1r in these compartments (29), suggesting expression in nonT cell hematopoietic or endothelial cells

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